2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Ser/Thr Protease

Ser/Thr Protease

Serine proteases; Serine endopeptidases; Threonine proteases

Ser/Thr Protease

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Serine (Ser) proteases catalyse the hydrolysis of specific peptide bonds in their substrates and this activity depends on a set of amino acids in the active site of the enzyme, one of which is always a serine. There are two families especially well studied, the trypsin family and the subtilisin family. Serine proteases play crucial roles in a wide variety of cellular as well as extracellular functions, including the process of blood clotting, protein digestion, cell signaling, inflammation, and protein processing. Threonine (Thr) proteases are a family of proteolytic enzymes harbouring a threonine residue within the active site. The prototype members of this class of enzymes are the catalytic subunits of the proteasome, however the acyltransferases convergently evolved the same active site geometry and mechanism.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-E70586
    Elastase (high purity)
    Elastase (high purity) is a serine protease that hydrolyzes proteins and peptides.
    Elastase (high purity)
  • HY-P4366
    Tos-Gly-Pro-Lys-AMC
    Tos-Gly-Pro-Lys-AMC is a fluorogenic peptide substrate of tryptase.
    Tos-Gly-Pro-Lys-AMC
  • HY-145292
    TNIK-IN-2
    		Inhibitor 99.68%
    TNIK-IN-2 is a Traf2- and Nck-interacting protein kinase (TNIK) inhibitor, with an IC50 of 1.3337 μM. TNIK-IN-2 can be used for the study of colorectal cancer (CRC).
    TNIK-IN-2
  • HY-P4332
    Boc-Glu(OBzl)-Ala-Arg-AMC
    		Substrate
    Boc-Glu(OBzl)-Ala-Arg-AMC is a fluorogenic substrate for coagulation factor XIa and trypsin. The cleavage of the amide bond between arginine and the methylcoumarin amide group releases fluorescent 7-Amino-4-methylcoumarin (HY-D0027).
    Boc-Glu(OBzl)-Ala-Arg-AMC
  • HY-P990533
    Anti-TPSAB1 Antibody
    Anti-TPSAB1 Antibody is a CHO-expressed human antibody that targets TPSAB1. The Anti-TPSAB1 Antibody has a huIgG4SP type heavy chain and a huκ type light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for the Anti-TPSAB1 Antibody can be referenced as Human IgG4 kappa, Isotype Control (HY-P99003).
    Anti-TPSAB1 Antibody
  • HY-143867
    Kallikrein-IN-2
    		Inhibitor
    Kallikrein-IN-2 (compound 1) is a Kallikrein inhibitor.
    Kallikrein-IN-2
  • HY-P990431
    Anti-HGFA Antibody
    		Inhibitor
    Anti-HGFA Antibody is a humanized antibody expressed in CHO cells, targeting HGFA. The Anti-HGFA Antibody contains huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-HGFA Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).
    Anti-HGFA Antibody
  • HY-P11335
    Oscillamide Y
    		Inhibitor
    Oscillamide Y (Compound 1), a ureido-containing cyclic peptide, is a Chymotrypsin inhibitor. Oscillamide Y can be isolated from freshwater toxic cyanobacterium Oscillatoria agardhii. Oscillamide Y has potent toxicity against fish, daphnid magna and algae with a stimulatory effect for Raphidocelis subcapitata (EC50: 4.62 mg/L). Oscillamide Y induces high luminescence inhibition in Aliivibrio fischeri. Oscillamide Y can be used for ecological development research.
    Oscillamide Y
  • HY-P5377
    Abz-HPGGPQ-EDDnp
    Abz-HPGGPQ-EDDnp (Cathepsin K substrate) is a biological active peptide. (Cathepsins are a class of globular lysosomal proteases, playing a vital role in mammalian cellular turnover. They degrade polypeptides and are distinguished by their substrate specificities. Cathepsin K is the lysosomal cysteine protease involved in bone remodeling and resorption. It has potential as a drug target in autoimmune diseases and osteoporosis.This FRET peptide can be used to monitor selectively cathepsin K activity in physiological fluids and cell lysates. Abz-HPGGPQ-EDDnp [where Abz represents o-aminobenzoic acid and EDDnp represents N -(2, 4-dinitrophenyl)-ethylenediamine], a substrate initially developed for trypanosomal enzymes, is efficiently cleaved at the Gly-Gly bond by cathepsin K. This peptide is resistant to hydrolysis by cathepsins B, F, H, L, S and V, Ex/Em=340 nm/420 nm.)
    Abz-HPGGPQ-EDDnp
  • HY-E70567
    Protease (Gly Cleaving)
    Protease (Gly Cleaving) can be used to digest flexible linkers of fusion proteins composed of glycine or glycine and serine residues, repeating sequences, such as (Gly4Ser)n, GlyxSery (GS), and poly-glycine (G) linkers.
    Protease (Gly Cleaving)
  • HY-15958A
    (S,R,R)-VBY-825
    		98.01%
    (S,R,R)-VBY-825 is the isomer of VBY-825 (HY-15958), and can be used as an experimental control. VBY-825 is a novel reversible inhibitor of cathepsin with high inhibition of cathepsin B, L, S and V.
    (S,R,R)-VBY-825
  • HY-N4333
    Rivulariapeptolides 988
    Rivulariapeptolides 988 is a high potent and selective serine protease inhibitor with IC50 values of 95.46 nM, 15.29 nM and 85.50 nM for chymotrypsin, elastase and proteinase K, respectively.
    Rivulariapeptolides 988
  • HY-P10572
    HG1 Toxin
    		Inhibitor
    HG1 Toxin is a peptide found in the venom of the scorpion Heterometrus fulvipes, which has the activity of inhibiting potassium channel Kv1.3. HG1 Toxin also has the activity of inhibiting trypsin (Ki=107 nM) and can be used in the study of autoimmune diseases.
    HG1 Toxin
  • HY-129047E
    Trypsin, porcine pancreas (Cell culture grade)
    Trypsin, porcine pancreas (Cell culture grade) is a serine protease enzyme that hydrolyzes proteins at the carboxyl side of the Lysine or Arginine. Trypsin, porcine pancreas (Cell culture grade) has an excellent protein digestibility for α-lactalbumin and β-casein. Trypsin, porcine pancreas (Cell culture grade) activates kallikrein and regulates the blood pressure. Trypsin, Human Pancreas is an activator for PAR, thereby regulating cellular inflammatory and immune responses.
    Trypsin, porcine pancreas (Cell culture grade)
  • HY-P4368
    Z-APF-CMK
    		Inhibitor
    Z-APF-CMK is a specific inhibitor of Ca2+-regulated nuclear scaffold protease (CRNSP).
    Z-APF-CMK
  • HY-126809
    Bz-Pro-Phe-Arg-pNA
    		Substrate
    Bz-Pro-Phe-Arg-pNA (Bz-PFR-pNA) is a chromogenic peptide substrate for plasma and glandular Kallikrein, cysteine proteinase (Cruzipain) and Trypsin. Bz-Pro-Phe-Arg-pNA can be used in Factor XII assay.
    Bz-Pro-Phe-Arg-pNA
  • HY-P5027
    Cbz-Lys-Arg-pNA
    		Substrate
    Cbz-Lys-Arg-pNA is a peptide substrate containing pNA as the chromogenic group. Cbz-Lys-Arg-pNA is widely used in enzymatic analysis, including thrombin, plasmin, factor Xa and Kallikrein.
    Cbz-Lys-Arg-pNA
  • HY-P4331
    Boc-Gln-Gly-Arg-AMC
    		Substrate
    Boc-Gln-Gly-Arg-AMC is a fluorogenic substrate for factor XIIa and trypsin. The cleavage of the amide bond between arginine and the methylcoumarin amide group releases fluorescent 7-Amino-4-methylcoumarin (HY-D0027).
    Boc-Gln-Gly-Arg-AMC
  • HY-18234AR
    Leupeptin hemisulfate (Standard)
    		Inhibitor
    Leupeptin (hemisulfate) (Standard) is the analytical standard of Leupeptin (hemisulfate). This product is intended for research and analytical applications. Leupeptin hemisulfate is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin hemisulfate potently inhibits serine, cysteine and threonine proteases. Leupeptin hemisulfate inhibits Mpro (the main protease of SARS-CoV-2) and also has anti-inflammatory activity[1][2][3].
    Leupeptin hemisulfate (Standard)
  • HY-114080A
    Patamostat mesylate
    		Inhibitor
    Patamostat (E-3123) mesylate is a potent protease inhibitor. Patamostat mesylate potently inhibits trypsin, plasmin and thrombin with IC50s of 39 nM, 950 nM and 1.9 μM, respectively. Patamostat mesylate may possess suppressing effects on pathogenesis and development of acute pancreatitis.
    Patamostat mesylate
Cat. No. Product Name / Synonyms Application Reactivity